Quote 4
"Well, we ain't got any," George exploded. "Whatever we ain't got, that's what you want. God a'mighty, if I was alone I could live so easy. I could go get a job an' work, an' no trouble. No mess at all, and when the end of the month come I could take my fifty bucks and go into town and get whatever I want. Why, I could stay in a cathouse all night. I could eat any place I want, hotel or any place, and order any damn thing I could think of. An' I could do all that every damn month. Get a gallon of whisky, or set in a pool room and play cards or shoot pool." Lennie knelt and looked over the fire at the angry George. And Lennie's face was drawn in with terror. "An' whatta I got," George went on furiously. "I got you! You can't keep a job and you lose me ever' job I get. Jus' keep me shovin' all over the country all the time." (1.89)
During this little temper tantrum George basically says that he wishes he were alone so he could go to as many whorehouses as he wanted. You know, just like we sometimes wished we lived alone so we could eat chocolate cake at 2AM without anyone judging us.
Quote 5
"I seen the guys that go around on the ranches alone. That ain't no good. They don't have no fun. After a long time they get mean. They get wantin' to fight all the time." (3.17)
The first rule of Ranch Fight Club is don't talk about Ranch Fight Club. Actually, talking is exactly what they need to do, otherwise all human interactions will just be combative, which will make them more lonely and more combative and more lonely and...you get the idea.
Quote 6
George half-closed his eyes. "I gotta think about that. We was always gonna do it by ourselves." Candy interrupted him, "I'd make a will an' leave my share to you guys in case I kick off, 'cause I ain't got no relatives or nothing…" (3.218-219)
Candy is so isolated that he doesn't even have relatives to leave his money to.